Core Service Pillar 5

Evidence Synthesis & Scientific Publications

Publication-grade Systematic Literature Reviews (SLR), quantitative Meta-Analyses, and high-impact peer-reviewed manuscripts conforming to PRISMA, Cochrane, and ICMJE guidelines.

From Complex Clinical Data to Peer-Reviewed Impact

Publishing in top-tier medical journals (Q1/Q2 impact factor) and supporting Health Technology Assessments (HTA) requires more than raw data; it demands immaculate research methodology, reproducible literature synthesis, and strict adherence to international publication ethics (ICMJE, GPP4, and COPE).

Kensai Health provides comprehensive evidence synthesis and medical publication services backed by decades of biopharma, CRO, and academic research rigor. Our senior evidence synthesis specialists and medical writers support biopharma sponsors, academic consortia, and clinical investigators from initial protocol conceptualization through peer-review acceptance.

We synthesize vast clinical datasets into authoritative systematic reviews, quantitative meta-analyses, and compelling trial manuscripts that withstand intense scientific scrutiny.

Methodological Rigor & Ethical Standards

Every systematic review and manuscript adheres strictly to PRISMA 2020 reporting criteria, PROSPERO registration standards, and ICMJE authorship guidelines.

Evidence Synthesis Capabilities

  • ✓ Peer-Reviewed Manuscripts: Primary clinical trial readouts, secondary analyses, and review articles.
  • ✓ PRISMA Systematic Reviews: Registered protocols (PROSPERO), dual screening, and evidence tables.
  • ✓ Quantitative Meta-Analyses: Forest plots, heterogeneity testing (I²), and subgroup modeling.
  • ✓ Targeted Literature Reviews (TLR): Rapid landscape analyses for HTA dossiers and clinical strategy.
  • ✓ Journal Submission Steering: Rebuttal letters, peer-review critique management, and galley checks.
Evidence Synthesis Solutions

Comprehensive Publication & Synthesis Portfolio

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Peer-Reviewed Journal Manuscripts

Complete manuscript authoring and editing for primary clinical trial results, retrospective cohort studies, and secondary post-hoc analyses. We ensure adherence to target journal Instructions for Authors, ICMJE criteria, and EQUATOR guidelines (CONSORT, STROBE).

  • • Primary clinical trial papers
  • • Post-hoc & subgroup analysis papers
  • • Expert reviews & clinical consensus reports
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Systematic Literature Reviews (SLR)

Exhaustive, reproducible systematic reviews conforming to PRISMA 2020 guidelines and Cochrane Handbook methodologies. We build sensitive database search algorithms across PubMed, Embase, Scopus, Web of Science, and Cochrane Central.

  • • PROSPERO protocol pre-registration
  • • Rayyan / Covidence dual screening support
  • • Risk-of-bias assessment (Cochrane RoB 2 / ROBINS-I)
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Quantitative Meta-Analysis

Pooling trial data across published studies to evaluate overall treatment effect sizes, odds ratios, hazard ratios, and relative risks. We construct publication-ready forest plots and funnel plots to assess publication bias.

  • • Fixed-effects and random-effects models
  • • Heterogeneity assessment (Cochran Q & I² statistic)
  • • Egger's test and Begg's funnel plots
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Bibliometric & Landscape Analysis

Quantitative mapping of clinical trial landscapes, emerging therapeutic trends, co-citation networks, and institutional collaboration patterns using specialized bibliometric analytical tools (VOSviewer, Bibliometrix).

  • • Mapping therapeutic evolution over time
  • • Clinical trial keyword & mesh term clustering
  • • Competitive scientific pipeline intelligence
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Health Technology & Outcomes Support

Generating targeted clinical evidence syntheses to support Health Economics and Outcomes Research (HEOR), value dossiers, comparative effectiveness evaluations, and payer submissions.

  • • Targeted Literature Reviews (TLR)
  • • Comparative clinical efficacy extraction
  • • Value dossier evidence synthesis
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Peer-Review Rebuttals & Journal Steering

Managing rigorous journal peer-review feedback. We assist authors and steering committees in drafting detailed, respectful, and point-by-point rebuttal letters and revising manuscripts to secure final acceptance.

  • • Target journal impact factor benchmarking
  • • Point-by-point reviewer rebuttal matrices
  • • Post-acceptance proofreading & galley checks
Peer-Reviewed Track Record

Selected Publications & Editorial Contributions

Demonstrated scholarly authority across digital therapeutics, clinical trials, and medical communication standards.

BMJ Innovations

Harnessing technology for diabetes care: a review of digital therapeutics

BMJ Innovations. 2026;12(2):110-118.

Comprehensive peer-reviewed synthesis of digital therapeutics in clinical practice, exploring regulatory frameworks, adoption enablers, and clinical glycemic efficacy.

Edward Elgar Publishing

Sustainable digital health: integrating AI and circular economy principles

Handbook on Artificial Intelligence and the Circular Economy. 2026.

Book chapter synthesizing AI applications in sustainable healthcare ecosystems, clinical data governance, and technology adoption frameworks.

Proceedings of Singapore Healthcare

Deciphering the evolution of digital therapeutics: A bibliometric analysis

Proc Singapore Healthc. 2025;34.

Quantitative bibliometric mapping of clinical trials and global research networks investigating digital therapeutic technologies over a 20-year horizon.

BMC Pulmonary Medicine • Clinical Trial

Effect of MN-166 (ibudilast) on acute respiratory failure prevention in COVID-19

BMC Pulm Med 2026;26:218.

Randomized, double-blind, placebo-controlled Phase 2 trial investigating MN-166 in hospitalized patients with acute respiratory failure.

Plan Your Systematic Review or Journal Manuscript

Partner with experienced evidence synthesis methodologists and senior medical writers to bring your clinical evidence into high-impact peer-reviewed literature.